What is PCI Express? Do PCIe lanes, slots, and versions matter?

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On current Intel single socket systems a PCIe switch is required to get 4 full X16 slots for GPU's The alternative possibility for 4 GPU's on Yes, the size of a graphics card does matter, especially when it comes to fitting it into your computer case Some high-end graphics cards can be quite large

pragmatic demo slot When it comes to PCIe lanes, graphics cards are the most hungry for them The top-tier GPUs like Nvidia RTX 2080 Ti and AMD's Radeon VII require HOWEVER, the manual indicates all of the expansion slots as being x16 I'm assuming that this means that any of the slots will run my GPU x16